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Long-term theophylline use by patients with COPD results in improvement in other aspects of lung function, including vital capacity, FEV 1, minute ventilation, and gas exchange. In addition to its effect on airflow resistance, theophylline may enhance the ventilatory pump. It is a respiratory stimulant in normal humans. As I wrote in 2009, the manufacturer Otsuka tapped a much larger market for Abilify as an add-on treatment for depression. I objected to the consumer ad campaign that trumpeted this expensive, dangerous niche product for common depression. While there's a role for Abilify in unusually severe, unresponsive depression, advertising it widely as a benign "boost" for one's antidepressant. COPD, additional medications may be used, such as theophylline and roflumilast. • Theophylline, a non-selective phosphodiesterase inhibitor, is an older medication that has significant side effects including headache, nausea and vomiting, restlessness and arrhythmias. 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